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Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c-Kit Expression in Rats with SCI-Induced Neurogenic Bowel Dysfunction
Joint Authors
Zhu, Zhaojin
Zhang, Wenyi
Xie, Bin
Yang, Yujie
Cheng, Jie
Zhang, Yongni
Guo, Jiabao
Zhu, Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Electroacupuncture (EA) could improve colonic transit activity in rats with neurogenic bowel dysfunction (NBD) caused by spinal cord injury (SCI).
The function of interstitial cells of Cajal (ICCs) and c-Kit expression may play essential roles in this process.
Material and Methods.
Thirty-six Sprague Dawley rats were randomized to the sham group, the SCI group, or the SCI + EA group (bilateral Zusanli, 30 min/day, 14 days).
Changes in the ultrastructural morphology of ICCs were observed.
The c-Kit expression on different levels was analyzed by immunohistochemistry, Western blotting, and RT-qPCR, respectively.
Results.
Abnormal morphology of ICCs and downregulation of the c-Kit expression occurred after SCI.
While the number of ICCs was increased, the ultrastructural morphology was improved significantly in EA rats.
They also showed better improvement in c-Kit expression at both protein and gene levels.
Conclusion.
Abnormal ICCs in colon tissues and the downregulated expression of c-Kit could be observed after SCI.
EA at Zusanli (ST36) could improve the colon function by repairing the morphology and increasing the number of ICCs and upregulating c-Kit expression.
American Psychological Association (APA)
Yang, Yujie& Cheng, Jie& Zhang, Yongni& Guo, Jiabao& Xie, Bin& Zhang, Wenyi…[et al.]. 2020. Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c-Kit Expression in Rats with SCI-Induced Neurogenic Bowel Dysfunction. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158229
Modern Language Association (MLA)
Yang, Yujie…[et al.]. Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c-Kit Expression in Rats with SCI-Induced Neurogenic Bowel Dysfunction. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158229
American Medical Association (AMA)
Yang, Yujie& Cheng, Jie& Zhang, Yongni& Guo, Jiabao& Xie, Bin& Zhang, Wenyi…[et al.]. Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c-Kit Expression in Rats with SCI-Induced Neurogenic Bowel Dysfunction. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158229