Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction

المؤلفون المشاركون

Liang, Bo
Fu, Ling
Liao, Hui-Ling
Zhou, Yan

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-03-20

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

Dingji Fumai decoction (DFD) is used to treat ventricular arrhythmia, and it has provided a very good curative effect.

However, its cellular electrophysiological mechanism is unknown.

Methods.

Electrocardiogram was recorded, and oxidative stress response and ion-channel-related molecules were detected in rats with barium chloride- and aconitine-induced ventricular arrhythmia.

Moreover, whole-cell patch-clamp assay was used to investigate the inhibitory effect of DFD on Nav1.5 in Chinese hamster ovary cells.

Results.

DFD prolonged the occurrence time and shortened the duration of ventricular arrhythmia, decreased the malondialdehyde and increased the superoxide dismutase, and alleviated the activation of Na+-K+-ATPase and connexin-43.

DFD suppressed Nav1.5dose-dependently with an IC50 of 24.0 ± 2.4 mg/mL.

Conclusions.

The clinical antiarrhythmic mechanisms of DFD are based on its antioxidant potential, alleviation of Na+-K+-ATPase and connexin-43, and class I antiarrhythmic properties by suppressing Nav1.5dose-dependently with an IC50 of 24.0 ± 2.4 mg/mL.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liang, Bo& Zhou, Yan& Fu, Ling& Liao, Hui-Ling. 2020. Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158396

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liang, Bo…[et al.]. Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158396

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liang, Bo& Zhou, Yan& Fu, Ling& Liao, Hui-Ling. Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158396

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1158396