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Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction
Joint Authors
Liang, Bo
Fu, Ling
Liao, Hui-Ling
Zhou, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Dingji Fumai decoction (DFD) is used to treat ventricular arrhythmia, and it has provided a very good curative effect.
However, its cellular electrophysiological mechanism is unknown.
Methods.
Electrocardiogram was recorded, and oxidative stress response and ion-channel-related molecules were detected in rats with barium chloride- and aconitine-induced ventricular arrhythmia.
Moreover, whole-cell patch-clamp assay was used to investigate the inhibitory effect of DFD on Nav1.5 in Chinese hamster ovary cells.
Results.
DFD prolonged the occurrence time and shortened the duration of ventricular arrhythmia, decreased the malondialdehyde and increased the superoxide dismutase, and alleviated the activation of Na+-K+-ATPase and connexin-43.
DFD suppressed Nav1.5dose-dependently with an IC50 of 24.0 ± 2.4 mg/mL.
Conclusions.
The clinical antiarrhythmic mechanisms of DFD are based on its antioxidant potential, alleviation of Na+-K+-ATPase and connexin-43, and class I antiarrhythmic properties by suppressing Nav1.5dose-dependently with an IC50 of 24.0 ± 2.4 mg/mL.
American Psychological Association (APA)
Liang, Bo& Zhou, Yan& Fu, Ling& Liao, Hui-Ling. 2020. Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158396
Modern Language Association (MLA)
Liang, Bo…[et al.]. Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158396
American Medical Association (AMA)
Liang, Bo& Zhou, Yan& Fu, Ling& Liao, Hui-Ling. Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158396