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Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway
المؤلفون المشاركون
Wang, Jialong
Liu, Fang
Qu, Jingtian
Zhang, Xuezhu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Oroxylin A, a flavonoid, is naturally produced in many medicinal plants.
Our previous study identified it as a phytoestrogen.
Based on this, the present study investigated its vasoconstriction reducing effects and whether the action was mediated by the estrogen receptor (ER) signal pathway.
Long-term in vitro treatment with oroxylin A reduced Ach-induced vasorelaxation and NE-mediated or KCl-mediated contractile responses in rat aortic rings.
These effects were interfered by an ER inhibitor ICI 182,780.
Rat cardiac microvascular endothelial cells (CMECs) and aortic vascular smooth muscle cells (VSMCs) were used to study the possible underlying mechanisms.
Oroxylin A activated the ER signal pathway.
In CMECs, it increased NO production and eNOS protein expression.
In VSMCs, it promoted NO production and iNOS protein expression.
These effects were also inhibited by ICI 182,780.
Besides, oroxylin A stimulated ERα and ERβ protein expression in CMECs and VSMCs.
All these findings suggest that the ER signal pathway takes part in the vasoconstriction reducing effects of oroxylin A.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qu, Jingtian& Liu, Fang& Zhang, Xuezhu& Wang, Jialong. 2020. Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1158435
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qu, Jingtian…[et al.]. Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1158435
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qu, Jingtian& Liu, Fang& Zhang, Xuezhu& Wang, Jialong. Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1158435
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158435
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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