Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway
Joint Authors
Wang, Jialong
Liu, Fang
Qu, Jingtian
Zhang, Xuezhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oroxylin A, a flavonoid, is naturally produced in many medicinal plants.
Our previous study identified it as a phytoestrogen.
Based on this, the present study investigated its vasoconstriction reducing effects and whether the action was mediated by the estrogen receptor (ER) signal pathway.
Long-term in vitro treatment with oroxylin A reduced Ach-induced vasorelaxation and NE-mediated or KCl-mediated contractile responses in rat aortic rings.
These effects were interfered by an ER inhibitor ICI 182,780.
Rat cardiac microvascular endothelial cells (CMECs) and aortic vascular smooth muscle cells (VSMCs) were used to study the possible underlying mechanisms.
Oroxylin A activated the ER signal pathway.
In CMECs, it increased NO production and eNOS protein expression.
In VSMCs, it promoted NO production and iNOS protein expression.
These effects were also inhibited by ICI 182,780.
Besides, oroxylin A stimulated ERα and ERβ protein expression in CMECs and VSMCs.
All these findings suggest that the ER signal pathway takes part in the vasoconstriction reducing effects of oroxylin A.
American Psychological Association (APA)
Qu, Jingtian& Liu, Fang& Zhang, Xuezhu& Wang, Jialong. 2020. Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1158435
Modern Language Association (MLA)
Qu, Jingtian…[et al.]. Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1158435
American Medical Association (AMA)
Qu, Jingtian& Liu, Fang& Zhang, Xuezhu& Wang, Jialong. Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1158435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158435