![](/images/graphics-bg.png)
Network Pharmacology-Based Study on the Mechanism of Pinellia ternata in Asthma Treatment
المؤلفون المشاركون
Xia, Qing
Zhang, Shanshan
Lyu, Yanmin
Chen, Xiangjing
Yao, Chengfang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Pinellia ternata (PT), a medicinal plant, has had an extensive application in the treatment of asthma in China, whereas its underlying pharmacological mechanisms remain unclear.
Methods.
Firstly, a network pharmacology method was adopted to collect activated components of PT from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP).
Targets of PT were assessed by exploiting the PharmMapper website; asthma-related targets were collected from the OMIM website, and target-target interaction networks were built.
Secondly, critical nodes exhibiting high possibility were identified as the hub nodes in the network, which were employed to conduct Gene Ontology (GO) comment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis.
Finally, the tissue expression profiles of key candidate genes were identified by the Gene Expression Omnibus (GEO) database, and the therapeutic effect of PT was verified by an animal experiment.
Results.
57 achievable targets of PT on asthma were confirmed as hub nodes through using the network pharmacology method.
As revealed from the KEGG enrichment analysis, the signaling pathways were notably enriched in pathways of the T-cell receptor signaling pathway, JAK-STAT signaling pathway, and cytokine-cytokine receptor interaction.
The expression profiles of candidate genes including Mmp2, Nr3c1, il-10, il-4, il-13, il-17a, il-2, tlr4, tlr9, ccl2, csf2, and vefgα were identified.
Moreover, according to transcriptome RNA sequencing data from lung tissues of allergic mice compared to normal mice, the mRNA level of Mmp2 and il-4 was upregulated (P<0.001).
In animal experiments, PT could alleviate the allergic response of mice by inhibiting the activation of T-helper type 2 (TH2) cells and the expression of Mmp2 and il-4.
Conclusions.
Our study provides candidate genes that may be either used for future studies related to diagnosis/prognosis or as targets for asthma management.
Besides, animal experiments showed that PT could treat asthma by regulating the expression of Mmp2 and il-4.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lyu, Yanmin& Chen, Xiangjing& Xia, Qing& Zhang, Shanshan& Yao, Chengfang. 2020. Network Pharmacology-Based Study on the Mechanism of Pinellia ternata in Asthma Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158684
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lyu, Yanmin…[et al.]. Network Pharmacology-Based Study on the Mechanism of Pinellia ternata in Asthma Treatment. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1158684
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lyu, Yanmin& Chen, Xiangjing& Xia, Qing& Zhang, Shanshan& Yao, Chengfang. Network Pharmacology-Based Study on the Mechanism of Pinellia ternata in Asthma Treatment. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158684
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158684
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)