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In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro
المؤلفون المشاركون
Lozic, Marin
Stambolija, Vasilije
Krezic, Ivan
Dugandzic, Aleksandra
Zivanovic-Posilovic, Gordana
Gojkovic, Slaven
Kovacevic, Josip
Vrdoljak, Luka
Mirkovic, Ivan
Kokot, Antonio
Petrovic, Andreja
Pavlov, Katarina Horvat
Drmic, Domagoj
Suran, Jelena
Blagaic, Alenka Boban
Seiwerth, Sven
Sikiric, Predrag
المصدر
Emergency Medicine International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Recently, the pentadecapeptide BPC 157-induced counteraction of bupivacaine cardiotoxicity has been reported.
Medication includes (i) lidocaine-induced local anesthesia via intraplantar application and axillary and spinal (L4-L5) intrathecal block, (ii) lidocaine-induced arrhythmias, (iii) convulsions, and (iv) lidocaine-induced HEK293 cell depolarisation.
BPC 157 applications (intraplantar, intraperitoneal, and intragastric) were given (i) immediately after lidocaine, (ii) 10 min after, or (iii) 5 min before.
The BPC 157/NO-system relationship was verified with NO-agents, the NOS-blocker L-NAME and the NOS-substrate L-arginine, given alone and/or together, in axillary and spinal intrathecal blocks.
BPC 157 applied immediately after lidocaine or 5 min before the application of lidocaine considerably ameliorated plantar presentation.
BPC 157 medication considerably counteracted lidocaine-induced limb function failure; L-NAME was counteracted; L-arginine exhibited counteraction when given immediately after lidocaine, but prolongation was seen when given later.
Given together, prophylactically or therapeutically, L-NAME and L-arginine (L-NAME + L-arginine) counteracted the other’s response.
BPC 157 maintained its original response when given together with L-NAME or L-arginine.
When BPC 157 was given together with L-NAME and L-arginine, its original response reappeared.
BPC 157 antagonised the lidocaine-induced bradycardia and eliminated tonic-clonic convulsions.
Also, BPC 157 counteracted the lidocaine-induced depolarisation of HEK293 cells.
Thus, BPC 157 has antidote activity in its own right against lidocaine and local anesthetics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lozic, Marin& Stambolija, Vasilije& Krezic, Ivan& Dugandzic, Aleksandra& Zivanovic-Posilovic, Gordana& Gojkovic, Slaven…[et al.]. 2020. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1159082
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lozic, Marin…[et al.]. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1159082
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lozic, Marin& Stambolija, Vasilije& Krezic, Ivan& Dugandzic, Aleksandra& Zivanovic-Posilovic, Gordana& Gojkovic, Slaven…[et al.]. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1159082
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159082
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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