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In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro
Joint Authors
Lozic, Marin
Stambolija, Vasilije
Krezic, Ivan
Dugandzic, Aleksandra
Zivanovic-Posilovic, Gordana
Gojkovic, Slaven
Kovacevic, Josip
Vrdoljak, Luka
Mirkovic, Ivan
Kokot, Antonio
Petrovic, Andreja
Pavlov, Katarina Horvat
Drmic, Domagoj
Suran, Jelena
Blagaic, Alenka Boban
Seiwerth, Sven
Sikiric, Predrag
Source
Emergency Medicine International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Recently, the pentadecapeptide BPC 157-induced counteraction of bupivacaine cardiotoxicity has been reported.
Medication includes (i) lidocaine-induced local anesthesia via intraplantar application and axillary and spinal (L4-L5) intrathecal block, (ii) lidocaine-induced arrhythmias, (iii) convulsions, and (iv) lidocaine-induced HEK293 cell depolarisation.
BPC 157 applications (intraplantar, intraperitoneal, and intragastric) were given (i) immediately after lidocaine, (ii) 10 min after, or (iii) 5 min before.
The BPC 157/NO-system relationship was verified with NO-agents, the NOS-blocker L-NAME and the NOS-substrate L-arginine, given alone and/or together, in axillary and spinal intrathecal blocks.
BPC 157 applied immediately after lidocaine or 5 min before the application of lidocaine considerably ameliorated plantar presentation.
BPC 157 medication considerably counteracted lidocaine-induced limb function failure; L-NAME was counteracted; L-arginine exhibited counteraction when given immediately after lidocaine, but prolongation was seen when given later.
Given together, prophylactically or therapeutically, L-NAME and L-arginine (L-NAME + L-arginine) counteracted the other’s response.
BPC 157 maintained its original response when given together with L-NAME or L-arginine.
When BPC 157 was given together with L-NAME and L-arginine, its original response reappeared.
BPC 157 antagonised the lidocaine-induced bradycardia and eliminated tonic-clonic convulsions.
Also, BPC 157 counteracted the lidocaine-induced depolarisation of HEK293 cells.
Thus, BPC 157 has antidote activity in its own right against lidocaine and local anesthetics.
American Psychological Association (APA)
Lozic, Marin& Stambolija, Vasilije& Krezic, Ivan& Dugandzic, Aleksandra& Zivanovic-Posilovic, Gordana& Gojkovic, Slaven…[et al.]. 2020. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1159082
Modern Language Association (MLA)
Lozic, Marin…[et al.]. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1159082
American Medical Association (AMA)
Lozic, Marin& Stambolija, Vasilije& Krezic, Ivan& Dugandzic, Aleksandra& Zivanovic-Posilovic, Gordana& Gojkovic, Slaven…[et al.]. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1159082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159082