Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen
المؤلفون المشاركون
Lee, Hyun Seok
Ohmoto, Yasukazu
Seto, Yasuyuki
Kwon, Yong Hwan
Nam, Su Youn
Ishibashi, Yuko
Ohtsu, Hiroshi
Yang, Hae Min
Nomura, Sachiyo
Jeon, Seong Woo
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
The serum pepsinogen test has limitation in its predictive power as a noninvasive biomarker for gastric cancer screening.
We aimed to investigate whether the combination of TFF3 and pepsinogen could be an effective biomarker for the detection of gastric cancer even in the early stages.
Methods.
In total, 281 patients with early gastric cancer (EGC), who underwent endoscopic submucosal dissection in Korea, and 708 healthy individuals from Japan were enrolled in the derivation cohort.
The validation cohort included 30 Korean patients with EGC and 30 Korean healthy control blood donors.
Serum TFF3 levels were examined using enzyme-linked immunosorbent assay.
Results.
Using a cutoff of 6.73 ng/mL in the derivation cohort, the sensitivity of the combination of tests for EGC detection was superior (87.5%) to that of TFF3 (80.4%) or pepsinogen test alone (39.5%).
Similarly, in the validation cohort, the sensitivity of TFF3 plus pepsinogen was higher (90.4%) than that of TFF3 (80.0%) or pepsinogen test alone (33.3%).
Conclusion.
The combination of serum TFF3 and pepsinogen is a more effective noninvasive biomarker for gastric cancer detection compared with pepsinogen or TFF3 alone, even in EGC.
This trial is registered with NCT03046745.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Hyun Seok& Jeon, Seong Woo& Nomura, Sachiyo& Seto, Yasuyuki& Kwon, Yong Hwan& Nam, Su Youn…[et al.]. 2018. Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159210
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Hyun Seok…[et al.]. Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1159210
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Hyun Seok& Jeon, Seong Woo& Nomura, Sachiyo& Seto, Yasuyuki& Kwon, Yong Hwan& Nam, Su Youn…[et al.]. Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159210
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159210
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر