Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen
Joint Authors
Lee, Hyun Seok
Ohmoto, Yasukazu
Seto, Yasuyuki
Kwon, Yong Hwan
Nam, Su Youn
Ishibashi, Yuko
Ohtsu, Hiroshi
Yang, Hae Min
Nomura, Sachiyo
Jeon, Seong Woo
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The serum pepsinogen test has limitation in its predictive power as a noninvasive biomarker for gastric cancer screening.
We aimed to investigate whether the combination of TFF3 and pepsinogen could be an effective biomarker for the detection of gastric cancer even in the early stages.
Methods.
In total, 281 patients with early gastric cancer (EGC), who underwent endoscopic submucosal dissection in Korea, and 708 healthy individuals from Japan were enrolled in the derivation cohort.
The validation cohort included 30 Korean patients with EGC and 30 Korean healthy control blood donors.
Serum TFF3 levels were examined using enzyme-linked immunosorbent assay.
Results.
Using a cutoff of 6.73 ng/mL in the derivation cohort, the sensitivity of the combination of tests for EGC detection was superior (87.5%) to that of TFF3 (80.4%) or pepsinogen test alone (39.5%).
Similarly, in the validation cohort, the sensitivity of TFF3 plus pepsinogen was higher (90.4%) than that of TFF3 (80.0%) or pepsinogen test alone (33.3%).
Conclusion.
The combination of serum TFF3 and pepsinogen is a more effective noninvasive biomarker for gastric cancer detection compared with pepsinogen or TFF3 alone, even in EGC.
This trial is registered with NCT03046745.
American Psychological Association (APA)
Lee, Hyun Seok& Jeon, Seong Woo& Nomura, Sachiyo& Seto, Yasuyuki& Kwon, Yong Hwan& Nam, Su Youn…[et al.]. 2018. Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159210
Modern Language Association (MLA)
Lee, Hyun Seok…[et al.]. Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1159210
American Medical Association (AMA)
Lee, Hyun Seok& Jeon, Seong Woo& Nomura, Sachiyo& Seto, Yasuyuki& Kwon, Yong Hwan& Nam, Su Youn…[et al.]. Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159210