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Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy
المؤلفون المشاركون
Feres, Omar
Ribeiro da Rocha, José Joaquim
Parra, Rogério S.
Feitosa, Marley R.
Ribeiro, Letícia C. H.
Castro, Lais A.
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-08
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
Investigate the association between infliximab trough levels and quality of life in inflammatory bowel disease patients in maintenance therapy.
Methods.
We carried out a transversal study with inflammatory bowel disease patients in infliximab maintenance therapy.
Infliximab trough levels were determined using a quantitative rapid test.
Disease activity indices (partial Mayo Score and Harvey-Bradshaw Index) and endoscopic scores (endoscopic Mayo Score or Simple Endoscopic Score in Crohn’s disease) were obtained.
Quality of life was assessed using the Inflammatory Bowel Disease Questionnaire (IBDQ).
Results.
Seventy-one consecutive subjects were included in the study (55 with Crohn’s disease and 16 with ulcerative colitis).
Drug levels were considered satisfactory (≥3 μg/mL) in 28 patients (39.4%) and unsatisfactory (<3 μg/mL) in 43 (60.6%).
Satisfactory trough levels were associated with higher rates of clinical remission and mucosal healing.
Higher trough levels were also associated with improved IBDQ scores, particularly regarding bowel symptoms, systemic function, and social function.
Conclusion.
Satisfactory trough levels of infliximab were associated with higher rates of clinical remission, mucosal healing, and improved quality of life in inflammatory bowel disease patients on maintenance therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Parra, Rogério S.& Feitosa, Marley R.& Ribeiro, Letícia C. H.& Castro, Lais A.& Ribeiro da Rocha, José Joaquim& Feres, Omar. 2018. Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1159331
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Parra, Rogério S.…[et al.]. Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy. Gastroenterology Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1159331
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Parra, Rogério S.& Feitosa, Marley R.& Ribeiro, Letícia C. H.& Castro, Lais A.& Ribeiro da Rocha, José Joaquim& Feres, Omar. Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1159331
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159331
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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