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Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy
Joint Authors
Feres, Omar
Ribeiro da Rocha, José Joaquim
Parra, Rogério S.
Feitosa, Marley R.
Ribeiro, Letícia C. H.
Castro, Lais A.
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Investigate the association between infliximab trough levels and quality of life in inflammatory bowel disease patients in maintenance therapy.
Methods.
We carried out a transversal study with inflammatory bowel disease patients in infliximab maintenance therapy.
Infliximab trough levels were determined using a quantitative rapid test.
Disease activity indices (partial Mayo Score and Harvey-Bradshaw Index) and endoscopic scores (endoscopic Mayo Score or Simple Endoscopic Score in Crohn’s disease) were obtained.
Quality of life was assessed using the Inflammatory Bowel Disease Questionnaire (IBDQ).
Results.
Seventy-one consecutive subjects were included in the study (55 with Crohn’s disease and 16 with ulcerative colitis).
Drug levels were considered satisfactory (≥3 μg/mL) in 28 patients (39.4%) and unsatisfactory (<3 μg/mL) in 43 (60.6%).
Satisfactory trough levels were associated with higher rates of clinical remission and mucosal healing.
Higher trough levels were also associated with improved IBDQ scores, particularly regarding bowel symptoms, systemic function, and social function.
Conclusion.
Satisfactory trough levels of infliximab were associated with higher rates of clinical remission, mucosal healing, and improved quality of life in inflammatory bowel disease patients on maintenance therapy.
American Psychological Association (APA)
Parra, Rogério S.& Feitosa, Marley R.& Ribeiro, Letícia C. H.& Castro, Lais A.& Ribeiro da Rocha, José Joaquim& Feres, Omar. 2018. Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1159331
Modern Language Association (MLA)
Parra, Rogério S.…[et al.]. Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy. Gastroenterology Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1159331
American Medical Association (AMA)
Parra, Rogério S.& Feitosa, Marley R.& Ribeiro, Letícia C. H.& Castro, Lais A.& Ribeiro da Rocha, José Joaquim& Feres, Omar. Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1159331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159331