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RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Raj, Rishi
Asadipooya, Kamyar
Lankarani, Kamran B.
Kalantar Hormozi, Mohammadreza
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Fatty liver is a rising global health concern, significantly increasing the burden of health care cost.
Nonalcoholic fatty liver disease (NAFLD) has a correlation with metabolic syndrome and its complications.
Method.
We reviewed the literature regarding the mechanisms of developing NAFLD through AGE-RAGE signaling.
Results.
NAFLD, metabolic syndrome, and production of advanced glycation end-products (AGEs) share many common risk factors and appear to be connected.
AGE induces production of the receptor for AGE (RAGE).
AGE-RAGE interaction contributes to fat accumulation in the liver leading to inflammation, fibrosis, insulin resistance, and other complications of the fatty liver disease.
The immune system, especially macrophages, has an important defense mechanism against RAGE pathway activities.
Conclusion.
Soluble form of RAGE (sRAGE) has the capability to reduce inflammation by blocking the interaction of AGE with RAGE.
However, sRAGE has some limitations, and the best method of usage is probably autotransplantation of transfected stem cells or monocytes, as a precursor of macrophages and Kupffer cells, with a virus that carries sRAGE to alleviate the harmful effects of AGE-RAGE signaling in the settings of fatty liver disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Asadipooya, Kamyar& Lankarani, Kamran B.& Raj, Rishi& Kalantar Hormozi, Mohammadreza. 2019. RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159367
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Asadipooya, Kamyar…[et al.]. RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease. International Journal of Endocrinology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1159367
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Asadipooya, Kamyar& Lankarani, Kamran B.& Raj, Rishi& Kalantar Hormozi, Mohammadreza. RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159367
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159367
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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