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RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease
Joint Authors
Raj, Rishi
Asadipooya, Kamyar
Lankarani, Kamran B.
Kalantar Hormozi, Mohammadreza
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Fatty liver is a rising global health concern, significantly increasing the burden of health care cost.
Nonalcoholic fatty liver disease (NAFLD) has a correlation with metabolic syndrome and its complications.
Method.
We reviewed the literature regarding the mechanisms of developing NAFLD through AGE-RAGE signaling.
Results.
NAFLD, metabolic syndrome, and production of advanced glycation end-products (AGEs) share many common risk factors and appear to be connected.
AGE induces production of the receptor for AGE (RAGE).
AGE-RAGE interaction contributes to fat accumulation in the liver leading to inflammation, fibrosis, insulin resistance, and other complications of the fatty liver disease.
The immune system, especially macrophages, has an important defense mechanism against RAGE pathway activities.
Conclusion.
Soluble form of RAGE (sRAGE) has the capability to reduce inflammation by blocking the interaction of AGE with RAGE.
However, sRAGE has some limitations, and the best method of usage is probably autotransplantation of transfected stem cells or monocytes, as a precursor of macrophages and Kupffer cells, with a virus that carries sRAGE to alleviate the harmful effects of AGE-RAGE signaling in the settings of fatty liver disease.
American Psychological Association (APA)
Asadipooya, Kamyar& Lankarani, Kamran B.& Raj, Rishi& Kalantar Hormozi, Mohammadreza. 2019. RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159367
Modern Language Association (MLA)
Asadipooya, Kamyar…[et al.]. RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease. International Journal of Endocrinology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1159367
American Medical Association (AMA)
Asadipooya, Kamyar& Lankarani, Kamran B.& Raj, Rishi& Kalantar Hormozi, Mohammadreza. RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159367