Clinical Characteristics in Patients with Triple Negative Breast Cancer

المؤلفون المشاركون

Shapiro, R.
Schwartz, Shira
Yeh, Janet
Wang, Annie
Kern, Elizabeth
Chun, Jennifer
Axelrod, Deborah
Guth, Amber A.
Schnabel, Freya

المصدر

International Journal of Breast Cancer

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-08-17

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Purpose.

The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis.

Methods.

Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016.

Results.

Out of a total of 1964 patients, 190 (10%) patients had TNBC.

The median age for both TNBC and non-TNBC was 59 years.

There was a significantly higher proportion of African American and Asian patients with TNBC (p=0.0003) compared to patients with non-TNBC.

BRCA1 and BRCA2 were significantly associated with TNBC (p<0.0001, p=0.0007).

A prior history of breast cancer was significantly associated with TNBC (p=0.0003).

There was no relationship observed between TNBC and a history of chemoprevention or patients who had a history of AH or LCIS.

Conclusions.

We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC.

In order to develop more effective treatments, better surveillance, and improved prevention strategies, it is necessary to improve our understanding of the population at risk for TNBC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yeh, Janet& Chun, Jennifer& Schwartz, Shira& Wang, Annie& Kern, Elizabeth& Guth, Amber A.…[et al.]. 2017. Clinical Characteristics in Patients with Triple Negative Breast Cancer. International Journal of Breast Cancer،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1159543

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yeh, Janet…[et al.]. Clinical Characteristics in Patients with Triple Negative Breast Cancer. International Journal of Breast Cancer No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1159543

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yeh, Janet& Chun, Jennifer& Schwartz, Shira& Wang, Annie& Kern, Elizabeth& Guth, Amber A.…[et al.]. Clinical Characteristics in Patients with Triple Negative Breast Cancer. International Journal of Breast Cancer. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1159543

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1159543