Clinical Characteristics in Patients with Triple Negative Breast Cancer
Joint Authors
Shapiro, R.
Schwartz, Shira
Yeh, Janet
Wang, Annie
Kern, Elizabeth
Chun, Jennifer
Axelrod, Deborah
Guth, Amber A.
Schnabel, Freya
Source
International Journal of Breast Cancer
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis.
Methods.
Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016.
Results.
Out of a total of 1964 patients, 190 (10%) patients had TNBC.
The median age for both TNBC and non-TNBC was 59 years.
There was a significantly higher proportion of African American and Asian patients with TNBC (p=0.0003) compared to patients with non-TNBC.
BRCA1 and BRCA2 were significantly associated with TNBC (p<0.0001, p=0.0007).
A prior history of breast cancer was significantly associated with TNBC (p=0.0003).
There was no relationship observed between TNBC and a history of chemoprevention or patients who had a history of AH or LCIS.
Conclusions.
We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC.
In order to develop more effective treatments, better surveillance, and improved prevention strategies, it is necessary to improve our understanding of the population at risk for TNBC.
American Psychological Association (APA)
Yeh, Janet& Chun, Jennifer& Schwartz, Shira& Wang, Annie& Kern, Elizabeth& Guth, Amber A.…[et al.]. 2017. Clinical Characteristics in Patients with Triple Negative Breast Cancer. International Journal of Breast Cancer،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1159543
Modern Language Association (MLA)
Yeh, Janet…[et al.]. Clinical Characteristics in Patients with Triple Negative Breast Cancer. International Journal of Breast Cancer No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1159543
American Medical Association (AMA)
Yeh, Janet& Chun, Jennifer& Schwartz, Shira& Wang, Annie& Kern, Elizabeth& Guth, Amber A.…[et al.]. Clinical Characteristics in Patients with Triple Negative Breast Cancer. International Journal of Breast Cancer. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1159543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159543