Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy
المؤلفون المشاركون
Goussous, Ghaleb
Jafferbhoy, Sadaf
Smyth, Niamh
Hammond, Lisette
Narayanan, Sankaran
Kirby, Robert Mark
Soumian, Soni
المصدر
International Journal of Breast Cancer
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity and specificity for sentinel node assessment.
The aim of this study was to assess the impact of OSNA on micrometastases detection rates and use of adjuvant chemotherapy.
A retrospective review of patients with sentinel node micrometastases over a five-year period was carried out and a comparison of micrometastases detection using OSNA and H&E techniques was made.
Out of 1285 patients who underwent sentinel node (SLN) biopsy, 76 patients had micrometastases.
Using H&E staining, 36 patients were detected with SLN micrometastases (9/year) in contrast to 40 patients in the OSNA year (40/year) (p<0.0001), demonstrating a fourfold increase with the use of OSNA.
In the OSNA group, there was also a proportional increase in Grade III, triple-negative, ER-negative, and HER-2-positive tumours being diagnosed with micrometastases.
Also on interactive PREDICT tool, the number of patients with a predicted 10-year survival benefit of more than 3% with adjuvant chemotherapy increased from 52 to 70 percent.
OSNA has resulted in an increased detection rate of micrometastases especially in patients with aggressive tumour biology.
This increased the number of patients who had a predicted survival benefit from adjuvant chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Goussous, Ghaleb& Jafferbhoy, Sadaf& Smyth, Niamh& Hammond, Lisette& Narayanan, Sankaran& Kirby, Robert Mark…[et al.]. 2017. Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. International Journal of Breast Cancer،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1159575
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Goussous, Ghaleb…[et al.]. Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. International Journal of Breast Cancer No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1159575
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Goussous, Ghaleb& Jafferbhoy, Sadaf& Smyth, Niamh& Hammond, Lisette& Narayanan, Sankaran& Kirby, Robert Mark…[et al.]. Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. International Journal of Breast Cancer. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1159575
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159575
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر