Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy
Joint Authors
Goussous, Ghaleb
Jafferbhoy, Sadaf
Smyth, Niamh
Hammond, Lisette
Narayanan, Sankaran
Kirby, Robert Mark
Soumian, Soni
Source
International Journal of Breast Cancer
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity and specificity for sentinel node assessment.
The aim of this study was to assess the impact of OSNA on micrometastases detection rates and use of adjuvant chemotherapy.
A retrospective review of patients with sentinel node micrometastases over a five-year period was carried out and a comparison of micrometastases detection using OSNA and H&E techniques was made.
Out of 1285 patients who underwent sentinel node (SLN) biopsy, 76 patients had micrometastases.
Using H&E staining, 36 patients were detected with SLN micrometastases (9/year) in contrast to 40 patients in the OSNA year (40/year) (p<0.0001), demonstrating a fourfold increase with the use of OSNA.
In the OSNA group, there was also a proportional increase in Grade III, triple-negative, ER-negative, and HER-2-positive tumours being diagnosed with micrometastases.
Also on interactive PREDICT tool, the number of patients with a predicted 10-year survival benefit of more than 3% with adjuvant chemotherapy increased from 52 to 70 percent.
OSNA has resulted in an increased detection rate of micrometastases especially in patients with aggressive tumour biology.
This increased the number of patients who had a predicted survival benefit from adjuvant chemotherapy.
American Psychological Association (APA)
Goussous, Ghaleb& Jafferbhoy, Sadaf& Smyth, Niamh& Hammond, Lisette& Narayanan, Sankaran& Kirby, Robert Mark…[et al.]. 2017. Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. International Journal of Breast Cancer،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1159575
Modern Language Association (MLA)
Goussous, Ghaleb…[et al.]. Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. International Journal of Breast Cancer No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1159575
American Medical Association (AMA)
Goussous, Ghaleb& Jafferbhoy, Sadaf& Smyth, Niamh& Hammond, Lisette& Narayanan, Sankaran& Kirby, Robert Mark…[et al.]. Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. International Journal of Breast Cancer. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1159575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159575