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miR-129-5p Inhibits Adipogenesis through Autophagy and May Be a Potential Biomarker for Obesity
المؤلفون المشاركون
Mu, Qian
Ning, Guang
Fu, Xue
Jin, Lina
Han, Luyu
Yuan, Yini
Wang, Hui
Yang, Jian
Zhou, Donglei
Zhang, Zhiguo
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Introduction.
Obesity has an unclear pathogenesis.
MicroRNAs (miRNAs) may function as biologically active molecules for obesity through regulating adipocyte differentiation.
This study aimed to identify how miR-129-5p (a specific miRNA) regulates adipogenesis in vitro and explore its possible role in the pathogenesis of obesity in humans.
Materials and Methods.
The miR-129-5p expression was detected in obese mouse models.
The effect of miR-129-5p on adipocyte differentiation was observed, and the adipose markers were analyzed.
Bioinformatics and dual-luciferase reporter assay were applied to predict and confirm the target genes of miR-129-5p.
The human serum samples were detected and analyzed.
Results.
miR-129-5p is highly expressed in adipose tissues of db/db mice.
Gain- and loss-of-function studies show that miR-129-5p could significantly inhibit adipocyte differentiation and white adipocyte browning in vitro and decreases the level of specific markers, such as FABP4, UCP1, and PPARγ, in mature white and brown adipocytes.
miR-129-5p directly targets ATG7 which is predicted with bioinformatics and confirmed by dual-luciferase reporter assay.
Serum miR-129-5p level was evidently elevated in patients with simple obesity (p<0.01) and correlates with obesity indices, including BMI (r = 0.407, p<0.029) and fat percentage (r = 0.394, p<0.038).
Conclusion.
miR-129-5p might target on the ATG7-related autophagy signaling network that regulates white and brown adipogenesis.
Importantly, the aforementioned results suggest serum miR-129-5p might be a potential biomarker and therapeutic target for obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Xue& Jin, Lina& Han, Luyu& Yuan, Yini& Mu, Qian& Wang, Hui…[et al.]. 2019. miR-129-5p Inhibits Adipogenesis through Autophagy and May Be a Potential Biomarker for Obesity. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159582
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Xue…[et al.]. miR-129-5p Inhibits Adipogenesis through Autophagy and May Be a Potential Biomarker for Obesity. International Journal of Endocrinology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1159582
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Xue& Jin, Lina& Han, Luyu& Yuan, Yini& Mu, Qian& Wang, Hui…[et al.]. miR-129-5p Inhibits Adipogenesis through Autophagy and May Be a Potential Biomarker for Obesity. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159582
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159582
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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