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Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study
المؤلفون المشاركون
Guidi, Luisa
Pugliese, Daniela
Papi, Claudio
Aratari, Annalisa
Festa, Stefano
Monterubbianesi, Rita
Scribano, Maria Lia
Ferraro, Pietro Manuel
Armuzzi, A.
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Aims.
Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited.
The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients.
Methods.
All UC patients receiving thiopurine monotherapy at three tertiary IBD centers from 1995 to 2015 were identified.
The primary endpoint was steroid-free clinical remission.
Secondary endpoints were mucosal healing (MH), defined as Mayo endoscopic subscore 0, long-term safety, and predictors of sustained clinical remission.
Results.
We identified 192 patients, contributing a total of 747 person-years of follow-up (median follow-up 36 months, range 1–210 months).
Steroid dependency was the most common indication for thiopurine treatment (58%).
Steroid-free remission occurred in 45.3% of patients; 36.3% stopped thiopurines because of treatment failure and 18.2% for adverse events or intolerance.
The cumulative probability of maintaining steroid-free remission while on thiopurine treatment was 87%, 76%, 67.6%, and 53.4% at 12, 24, 36, and 60 months, respectively.
MH occurred in 57.9% of patients after a median of 18 months (range 5–96).
No independent predictors of sustained clinical remission could be identified.
Conclusions.
Thiopurines represent an effective and safe long-term maintenance therapy for UC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pugliese, Daniela& Aratari, Annalisa& Festa, Stefano& Ferraro, Pietro Manuel& Monterubbianesi, Rita& Guidi, Luisa…[et al.]. 2018. Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pugliese, Daniela…[et al.]. Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1159642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pugliese, Daniela& Aratari, Annalisa& Festa, Stefano& Ferraro, Pietro Manuel& Monterubbianesi, Rita& Guidi, Luisa…[et al.]. Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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