Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study
Joint Authors
Guidi, Luisa
Pugliese, Daniela
Papi, Claudio
Aratari, Annalisa
Festa, Stefano
Monterubbianesi, Rita
Scribano, Maria Lia
Ferraro, Pietro Manuel
Armuzzi, A.
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aims.
Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited.
The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients.
Methods.
All UC patients receiving thiopurine monotherapy at three tertiary IBD centers from 1995 to 2015 were identified.
The primary endpoint was steroid-free clinical remission.
Secondary endpoints were mucosal healing (MH), defined as Mayo endoscopic subscore 0, long-term safety, and predictors of sustained clinical remission.
Results.
We identified 192 patients, contributing a total of 747 person-years of follow-up (median follow-up 36 months, range 1–210 months).
Steroid dependency was the most common indication for thiopurine treatment (58%).
Steroid-free remission occurred in 45.3% of patients; 36.3% stopped thiopurines because of treatment failure and 18.2% for adverse events or intolerance.
The cumulative probability of maintaining steroid-free remission while on thiopurine treatment was 87%, 76%, 67.6%, and 53.4% at 12, 24, 36, and 60 months, respectively.
MH occurred in 57.9% of patients after a median of 18 months (range 5–96).
No independent predictors of sustained clinical remission could be identified.
Conclusions.
Thiopurines represent an effective and safe long-term maintenance therapy for UC patients.
American Psychological Association (APA)
Pugliese, Daniela& Aratari, Annalisa& Festa, Stefano& Ferraro, Pietro Manuel& Monterubbianesi, Rita& Guidi, Luisa…[et al.]. 2018. Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159642
Modern Language Association (MLA)
Pugliese, Daniela…[et al.]. Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1159642
American Medical Association (AMA)
Pugliese, Daniela& Aratari, Annalisa& Festa, Stefano& Ferraro, Pietro Manuel& Monterubbianesi, Rita& Guidi, Luisa…[et al.]. Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159642