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Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism
المؤلفون المشاركون
Liu, Zhaoxiang
Mao, Jiangfeng
Xu, Hongli
Wang, Xi
Huang, Bingkun
Zheng, Junjie
Nie, Min
Zhang, Hongbing
Wu, Xueyan
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Congenital hypogonadotropic hypogonadism (CHH) patients with cryptorchidism history usually have poor spermatogenesis outcome, while researches focusing on this population are rare.
This study retrospectively evaluated gonadotropin-induced spermatogenesis outcome in CHH patients with cryptorchidism (n = 40).
One hundred and eighty-three CHH patients without cryptorchidism were served as control.
All patients received combined gonadotropins therapy (HCG and HMG) and were followed up for at least 6 months.
The median follow-up period was 24 (15, 33) months (totally 960 person-months).
Sperm (>0/ml) initially appeared in semen at a median of estimated 24 months (95% confidence interval (CI) 17.8–30.2).
Twenty (20/40, 50%) patients succeeded in producing sperms, and the average time to produce first sperm was 19 ± 8 months.
Five pregnancies were achieved in 9 (5/9, 56%) couples who desired for children.
Compared with CHH patients without cryptorchidism (n = 183), cryptorchid patients had longer median time for sperm appearance in semen (24 months vs.
15 months, P<0.001), lower rate of spermatogenesis (50% vs.
67%, P=0.032), and lower mean sperm concentration (1.9 (0.5, 8.6) million/ml vs.
11.1(1.0, 25.0) million/ml, P=0.006) at the last visit.
In conclusion, CHH patients with cryptorchidism require a longer period for gonadotropin-induced spermatogenesis.
The successful rate and sperm concentration were lower than patients without cryptorchidism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhaoxiang& Mao, Jiangfeng& Xu, Hongli& Wang, Xi& Huang, Bingkun& Zheng, Junjie…[et al.]. 2019. Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1159653
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhaoxiang…[et al.]. Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism. International Journal of Endocrinology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1159653
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhaoxiang& Mao, Jiangfeng& Xu, Hongli& Wang, Xi& Huang, Bingkun& Zheng, Junjie…[et al.]. Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1159653
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159653
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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