Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism
Joint Authors
Liu, Zhaoxiang
Mao, Jiangfeng
Xu, Hongli
Wang, Xi
Huang, Bingkun
Zheng, Junjie
Nie, Min
Zhang, Hongbing
Wu, Xueyan
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Congenital hypogonadotropic hypogonadism (CHH) patients with cryptorchidism history usually have poor spermatogenesis outcome, while researches focusing on this population are rare.
This study retrospectively evaluated gonadotropin-induced spermatogenesis outcome in CHH patients with cryptorchidism (n = 40).
One hundred and eighty-three CHH patients without cryptorchidism were served as control.
All patients received combined gonadotropins therapy (HCG and HMG) and were followed up for at least 6 months.
The median follow-up period was 24 (15, 33) months (totally 960 person-months).
Sperm (>0/ml) initially appeared in semen at a median of estimated 24 months (95% confidence interval (CI) 17.8–30.2).
Twenty (20/40, 50%) patients succeeded in producing sperms, and the average time to produce first sperm was 19 ± 8 months.
Five pregnancies were achieved in 9 (5/9, 56%) couples who desired for children.
Compared with CHH patients without cryptorchidism (n = 183), cryptorchid patients had longer median time for sperm appearance in semen (24 months vs.
15 months, P<0.001), lower rate of spermatogenesis (50% vs.
67%, P=0.032), and lower mean sperm concentration (1.9 (0.5, 8.6) million/ml vs.
11.1(1.0, 25.0) million/ml, P=0.006) at the last visit.
In conclusion, CHH patients with cryptorchidism require a longer period for gonadotropin-induced spermatogenesis.
The successful rate and sperm concentration were lower than patients without cryptorchidism.
American Psychological Association (APA)
Liu, Zhaoxiang& Mao, Jiangfeng& Xu, Hongli& Wang, Xi& Huang, Bingkun& Zheng, Junjie…[et al.]. 2019. Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1159653
Modern Language Association (MLA)
Liu, Zhaoxiang…[et al.]. Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism. International Journal of Endocrinology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1159653
American Medical Association (AMA)
Liu, Zhaoxiang& Mao, Jiangfeng& Xu, Hongli& Wang, Xi& Huang, Bingkun& Zheng, Junjie…[et al.]. Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1159653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159653