Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function
المؤلفون المشاركون
Yang, Qingtao
Sui, Xuxia
Cao, Junjun
Liu, Caixia
Zheng, Shukai
Bao, Mian
Huang, Yuanni
Wu, Kusheng
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Testosterone plays an important prenatal role in male testis development.
Bisphenol A (BPA) exposure during pregnancy affects testosterone levels and germ cell apoptosis of male pups, but little information is available for the mechanism.
The aim of the present study was to investigate the mechanism by which BPA alters testosterone levels and germ cell apoptosis.
Pregnant female C57BL/6J mice, throughout gestation, had access to drinking water containing BPA at 5 and 50 μg/mL.
Male pups were euthanized on postnatal days (PNDs) 1, 14, and 35.
Relative to control, BPA exposure at 5 and 50 μg/ml decreased testosterone level, as measured by chemiluminescent immunoassay, on PND14.
Real-time PCR indicated mRNA levels for steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage enzyme (CYP11A1), and 3-β-hydroxysteroid dehydrogenase/△-5-4 isomerase (3β-HSD) were significantly lower in the BPA pups compared to control.
Additionally, BPA increased the percentage of TUNEL-positive seminiferous tubules, decreased the mRNA level of Bcl-2, and increased Bax expression, indicative of increased apoptosis.
These results suggest that BPA exposure in utero decreases the testosterone concentration by decreasing steroidogenic enzymes (StAR, CYP11A1, and 3β-HSD).
Furthermore, BPA exposure increases the apoptosis of germ cells, which is associated with proapoptotic changes in the levels of Bcl-2 and Bax.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Qingtao& Sui, Xuxia& Cao, Junjun& Liu, Caixia& Zheng, Shukai& Bao, Mian…[et al.]. 2019. Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1159658
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Qingtao…[et al.]. Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function. International Journal of Endocrinology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1159658
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Qingtao& Sui, Xuxia& Cao, Junjun& Liu, Caixia& Zheng, Shukai& Bao, Mian…[et al.]. Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1159658
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159658
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر