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Comparative Proteome Analysis of Epicardial and Subcutaneous Adipose Tissues from Patients with or without Coronary Artery Disease
المؤلفون المشاركون
Gong, Fengying
Zhu, Hui juan
Pan, Hui
Li, Naishi
Wang, Lin jie
Yang, Hong bo
Sun, Wei
Zhao, Yu xing
Liu, Xue mei
Zeng, Yong
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background and Aims.
Owing to its unique anatomical structure and metabolism, epicardial adipose tissue (EAT) has attracted amount of attention in coronary artery disease (CAD) research.
Here, we analyzed differences in proteome composition in epicardial (EAT) and subcutaneous adipose tissues (SAT) from patients with or without CAD.
Methods.
EAT and SAT samples were collected from 6 CAD patients and 6 non-CAD patients.
Isobaric Tagging for Relative and Absolute Quantitation (iTRAQ) analysis combined with liquid chromatography tandem-mass spectrometry (LC-MS/MS) was performed to identify the differentially expressed proteins.
Results.
In total, 2348 proteins expressed in EAT and 2347 proteins expressed in SAT were separately identified.
385 differentially expressed proteins were found in EAT and 210 proteins were found in SAT in CAD patients compared to non-CAD patients.
Many proteins differentially expressed in EAT of CAD patients were involved in biological functions associated with CAD development such as cell-to-cell signaling and interaction, inflammatory response, and lipid metabolism.
Differential expressions of proteins (MMP9, S100A9, and clusterin) in EAT or SAT were involved in several signaling pathways such as mitochondrial dysfunction, acute phase inflammation, and LXR/RXR activation, which was confirmed by western blotting, and similar results were obtained.
Conclusions.
The largest profiles of differentially expressed proteins in EAT and SAT between CAD patients and non-CAD patients were identified.
The significant signal pathways, mitochondrial dysfunction, and LXR/RXR activation, which differential proteins were involved in, were firstly found to play roles in EAT of CAD patients, and clusterin was firstly found to be upregulated in EAT of CAD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Yu xing& Zhu, Hui juan& Pan, Hui& Liu, Xue mei& Wang, Lin jie& Yang, Hong bo…[et al.]. 2019. Comparative Proteome Analysis of Epicardial and Subcutaneous Adipose Tissues from Patients with or without Coronary Artery Disease. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159672
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Yu xing…[et al.]. Comparative Proteome Analysis of Epicardial and Subcutaneous Adipose Tissues from Patients with or without Coronary Artery Disease. International Journal of Endocrinology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1159672
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Yu xing& Zhu, Hui juan& Pan, Hui& Liu, Xue mei& Wang, Lin jie& Yang, Hong bo…[et al.]. Comparative Proteome Analysis of Epicardial and Subcutaneous Adipose Tissues from Patients with or without Coronary Artery Disease. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159672
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159672
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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