Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma
المؤلفون المشاركون
Liu, Jianhua
Zeng, Weiqiang
Huang, Chengzhi
Wang, Junjiang
Yang, Dongyang
Ma, Dong
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
To investigate whether mutation profiling and microsatellite instability (MSI) status were associated with clinicopathological features and the prognosis in metastatic colorectal cancer (mCRC), mutations in RAS (including KRAS, NRAS, and HRAS) and BRAF were determined by Sanger sequencing.
Tumor mismatch repair proteins and MSI status were examined using immunohistochemistry and polymerase chain reaction, respectively.
The clinical value of these abnormalities was statistically analyzed, and prognostic value of different treatment regimens was also evaluated.
Among 461 mCRC patients, mutations in RAS, BRAF, and MSI-high (MSI-H) status were observed in 45.3% (209/461), 5.6% (26/461), and 6.5% (30/461) of cases, respectively.
Brain metastasis and high carcinoembryonic antigen level were highly correlated with KRAS mutation (P=0.011 and P<0.001), and tumors from females or located in the right colon tended to harbor BRAF mutation (P=0.039 and P=0.001).
RAS/BRAF mutations may predict brain and/or lung metastases.
Although neither clinical nor prognostic importance of MSI status was identified in our study, KRAS and BRAF mutations were demonstrated to be independent prognostic factors for overall survival and progression-free survival.
Besides, in wild-type group, patients treated with chemotherapy plus targeted therapy exhibited the most favorable prognosis.
Therefore, RAS/BRAF mutations may serve as indicators for prognosis and treatment options in mCRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jianhua& Zeng, Weiqiang& Huang, Chengzhi& Wang, Junjiang& Yang, Dongyang& Ma, Dong. 2018. Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1159725
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jianhua…[et al.]. Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma. Gastroenterology Research and Practice No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1159725
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jianhua& Zeng, Weiqiang& Huang, Chengzhi& Wang, Junjiang& Yang, Dongyang& Ma, Dong. Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1159725
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159725
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر