Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma
Joint Authors
Liu, Jianhua
Zeng, Weiqiang
Huang, Chengzhi
Wang, Junjiang
Yang, Dongyang
Ma, Dong
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
To investigate whether mutation profiling and microsatellite instability (MSI) status were associated with clinicopathological features and the prognosis in metastatic colorectal cancer (mCRC), mutations in RAS (including KRAS, NRAS, and HRAS) and BRAF were determined by Sanger sequencing.
Tumor mismatch repair proteins and MSI status were examined using immunohistochemistry and polymerase chain reaction, respectively.
The clinical value of these abnormalities was statistically analyzed, and prognostic value of different treatment regimens was also evaluated.
Among 461 mCRC patients, mutations in RAS, BRAF, and MSI-high (MSI-H) status were observed in 45.3% (209/461), 5.6% (26/461), and 6.5% (30/461) of cases, respectively.
Brain metastasis and high carcinoembryonic antigen level were highly correlated with KRAS mutation (P=0.011 and P<0.001), and tumors from females or located in the right colon tended to harbor BRAF mutation (P=0.039 and P=0.001).
RAS/BRAF mutations may predict brain and/or lung metastases.
Although neither clinical nor prognostic importance of MSI status was identified in our study, KRAS and BRAF mutations were demonstrated to be independent prognostic factors for overall survival and progression-free survival.
Besides, in wild-type group, patients treated with chemotherapy plus targeted therapy exhibited the most favorable prognosis.
Therefore, RAS/BRAF mutations may serve as indicators for prognosis and treatment options in mCRC.
American Psychological Association (APA)
Liu, Jianhua& Zeng, Weiqiang& Huang, Chengzhi& Wang, Junjiang& Yang, Dongyang& Ma, Dong. 2018. Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1159725
Modern Language Association (MLA)
Liu, Jianhua…[et al.]. Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma. Gastroenterology Research and Practice No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1159725
American Medical Association (AMA)
Liu, Jianhua& Zeng, Weiqiang& Huang, Chengzhi& Wang, Junjiang& Yang, Dongyang& Ma, Dong. Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1159725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159725