Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort
المؤلفون المشاركون
Boltin, Doron
Dickman, Ram
Levi, Zohar
Perets, Tsachi Tsadok
Gingold-Belfer, Rachel
Dotan, Iris
Schmilovitz-Weiss, Hemda
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H.
pylori) infection.
The 13C-urea breath test result (C13-UBT) utilizes H.
pylori urease activity and is a highly accurate diagnostic assay.
We aimed to determine whether the magnitude of C13-UBT result is related to treatment success.
Methods.
Adult patients who underwent a first-time 13C-urea breath test between January 2010 and January 2016 were included.
In order to isolate a naïve test-and-treat population who were unlikely to have undergone an initial endoscopy-based H.
pylori test, we excluded patients > 45 years and those with a previous C13-UBT.
Data were extracted from the Clalit Health Services laboratory database.
Results.
A total of 94,590 subjects (36.1% male, age 28.5 ± 6.0 years) who underwent a first-time C13-UBT during the study period were included.
C13-UBT was positive in 48,509 (51.3%) subjects.
A confirmatory posttreatment C13-UBT was performed in 18,375 (37.8%), and eradication was successful in 12,018 (65.4%).
The mean C13-UBT recording was 20.6 ± 16.2 DOB in subjects with successful eradication and 19.5 ± 13.1 DOB in subjects with treatment failure (OR, 1.01; 95% CI 1.00-1.01, p<0.01).
Among patients in the upper quintile of C13-UBT measurement, eradication was achieved in 67.6%, compared to 62.6% in the lower quintile (OR, 1.22; 95% CI 1.11-1.35, p<0.01).
Subjects in the top 1 percentile (C13-UBT ≥ 70 DOB) achieved eradication in 75.0%, compared to 65.3% among subjects with C13-UBT < 70 DOB (OR, 1.59; 95% CI 1.05-2.41, p<0.01).
Conclusions.
The superiority in H.
pylori eradication observed in subjects with a higher C13-UBT DOB is small but significant.
Further studies should examine the physiological and microbiological basis for this finding.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Boltin, Doron& Levi, Zohar& Perets, Tsachi Tsadok& Schmilovitz-Weiss, Hemda& Gingold-Belfer, Rachel& Dickman, Ram…[et al.]. 2018. Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1165089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Boltin, Doron…[et al.]. Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1165089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Boltin, Doron& Levi, Zohar& Perets, Tsachi Tsadok& Schmilovitz-Weiss, Hemda& Gingold-Belfer, Rachel& Dickman, Ram…[et al.]. Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1165089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر