Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort
Joint Authors
Boltin, Doron
Dickman, Ram
Levi, Zohar
Perets, Tsachi Tsadok
Gingold-Belfer, Rachel
Dotan, Iris
Schmilovitz-Weiss, Hemda
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H.
pylori) infection.
The 13C-urea breath test result (C13-UBT) utilizes H.
pylori urease activity and is a highly accurate diagnostic assay.
We aimed to determine whether the magnitude of C13-UBT result is related to treatment success.
Methods.
Adult patients who underwent a first-time 13C-urea breath test between January 2010 and January 2016 were included.
In order to isolate a naïve test-and-treat population who were unlikely to have undergone an initial endoscopy-based H.
pylori test, we excluded patients > 45 years and those with a previous C13-UBT.
Data were extracted from the Clalit Health Services laboratory database.
Results.
A total of 94,590 subjects (36.1% male, age 28.5 ± 6.0 years) who underwent a first-time C13-UBT during the study period were included.
C13-UBT was positive in 48,509 (51.3%) subjects.
A confirmatory posttreatment C13-UBT was performed in 18,375 (37.8%), and eradication was successful in 12,018 (65.4%).
The mean C13-UBT recording was 20.6 ± 16.2 DOB in subjects with successful eradication and 19.5 ± 13.1 DOB in subjects with treatment failure (OR, 1.01; 95% CI 1.00-1.01, p<0.01).
Among patients in the upper quintile of C13-UBT measurement, eradication was achieved in 67.6%, compared to 62.6% in the lower quintile (OR, 1.22; 95% CI 1.11-1.35, p<0.01).
Subjects in the top 1 percentile (C13-UBT ≥ 70 DOB) achieved eradication in 75.0%, compared to 65.3% among subjects with C13-UBT < 70 DOB (OR, 1.59; 95% CI 1.05-2.41, p<0.01).
Conclusions.
The superiority in H.
pylori eradication observed in subjects with a higher C13-UBT DOB is small but significant.
Further studies should examine the physiological and microbiological basis for this finding.
American Psychological Association (APA)
Boltin, Doron& Levi, Zohar& Perets, Tsachi Tsadok& Schmilovitz-Weiss, Hemda& Gingold-Belfer, Rachel& Dickman, Ram…[et al.]. 2018. Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1165089
Modern Language Association (MLA)
Boltin, Doron…[et al.]. Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1165089
American Medical Association (AMA)
Boltin, Doron& Levi, Zohar& Perets, Tsachi Tsadok& Schmilovitz-Weiss, Hemda& Gingold-Belfer, Rachel& Dickman, Ram…[et al.]. Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1165089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165089