Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Cheng, Binbin
Lin, Wanfu
Ling, Changquan
Zhong, Mao-feng
Zhang, Yu-ren
Wang, Huan
Zhao, He-tong
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The role of platelet-to-lymphocyte ratio (PLR) in the prognosis of hepatocellular carcinoma (HCC) patients with different Barcelona Clinic Liver Cancer (BCLC) stages remains controversial.
This systematic review and meta-analysis aimed to determine the efficacy of PLR on HCC prognosis.
Five electronic databases were searched for clinical trials focusing on the role of PLR in the prognosis of HCC.
A total of 297 potential studies were initially identified, and 9 studies comprising 2449 patients were finally enrolled to evaluate the association between the pretreatment PLR and clinical outcomes of overall survival (OS), disease-free survival (DFS), and event occurrence in patients with HCC in different BCLC stages.
An elevated pretreatment PLR indicated unfavorable worse OS (HR = 1.73; 95% CI: (1.46, 2.04); P<0.00001) and DFS (HR = 1.30; 95% CI: (1.06, 1.60); P=0.01).
Subgroup analysis indicated that high PLR indicated poor OS among BCLC-B/C patients without heterogeneity, while PLR in BCLC-A patients indicated high statistical heterogeneity with I2 value of 78%.
As for the correlation between PLR and event occurrence, high PLR was related to poor clinical event occurrence only among BCLC-C patients, though obvious heterogeneity was observed in all different BCLC stages.
In conclusion, PLR may be a significant biomarker in the prognosis of HCC in different BCLC stages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Wanfu& Zhong, Mao-feng& Zhang, Yu-ren& Wang, Huan& Zhao, He-tong& Cheng, Binbin…[et al.]. 2018. Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165095
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Wanfu…[et al.]. Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1165095
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Wanfu& Zhong, Mao-feng& Zhang, Yu-ren& Wang, Huan& Zhao, He-tong& Cheng, Binbin…[et al.]. Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165095
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165095
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر