Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis
Joint Authors
Cheng, Binbin
Lin, Wanfu
Ling, Changquan
Zhong, Mao-feng
Zhang, Yu-ren
Wang, Huan
Zhao, He-tong
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The role of platelet-to-lymphocyte ratio (PLR) in the prognosis of hepatocellular carcinoma (HCC) patients with different Barcelona Clinic Liver Cancer (BCLC) stages remains controversial.
This systematic review and meta-analysis aimed to determine the efficacy of PLR on HCC prognosis.
Five electronic databases were searched for clinical trials focusing on the role of PLR in the prognosis of HCC.
A total of 297 potential studies were initially identified, and 9 studies comprising 2449 patients were finally enrolled to evaluate the association between the pretreatment PLR and clinical outcomes of overall survival (OS), disease-free survival (DFS), and event occurrence in patients with HCC in different BCLC stages.
An elevated pretreatment PLR indicated unfavorable worse OS (HR = 1.73; 95% CI: (1.46, 2.04); P<0.00001) and DFS (HR = 1.30; 95% CI: (1.06, 1.60); P=0.01).
Subgroup analysis indicated that high PLR indicated poor OS among BCLC-B/C patients without heterogeneity, while PLR in BCLC-A patients indicated high statistical heterogeneity with I2 value of 78%.
As for the correlation between PLR and event occurrence, high PLR was related to poor clinical event occurrence only among BCLC-C patients, though obvious heterogeneity was observed in all different BCLC stages.
In conclusion, PLR may be a significant biomarker in the prognosis of HCC in different BCLC stages.
American Psychological Association (APA)
Lin, Wanfu& Zhong, Mao-feng& Zhang, Yu-ren& Wang, Huan& Zhao, He-tong& Cheng, Binbin…[et al.]. 2018. Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165095
Modern Language Association (MLA)
Lin, Wanfu…[et al.]. Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1165095
American Medical Association (AMA)
Lin, Wanfu& Zhong, Mao-feng& Zhang, Yu-ren& Wang, Huan& Zhao, He-tong& Cheng, Binbin…[et al.]. Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165095