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The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy
المؤلفون المشاركون
Hua, Lin
Xin, Zhong
Shi, Ting-Ting
Wang, Hua
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background and Objective.
A previous study reported alterations in the intestinal microbiota in patients with Graves’ orbitopathy (GO).
Thyrotropin receptor autoantibody (TRAb) stimulates orbital and periorbital tissues and plays a pivotal role in the development of GO.
However, the association between gut microbiota and TRAb in GO patients has still remained elusive.
In this study, we explored the relationships between gut microbiota and GO-related traits, in which we applied a metabolic-network-driven analysis to identify GO trait-related modules and extracted significant operational taxonomic units (OTUs).
Methods.
In the present study, we profiled gut microbiota using 16S rRNA gene sequencing in 31 GO patients.
We performed metabolic-network-driven analysis to investigate the association between gut microbiota and GO-related traits (e.g., TRAb, TGAb, and TPOAb) in the combination of microbial effects.
Results.
Applying microbiome network analysis of cooccurrence patterns and analysis of topological properties, we found that s_Prevotella_copri and f_Prevotellaceae showed a significant correlation with TRAb.
In particular, we applied the latent class model to explore the association between gut microbiota and GO-related traits in the combination of microbial effects.
It was revealed that the subjects involved in the latent class model with the higher abundance of s_Prevotella_copri and g_Bacteroides had a higher TRAb level.
Conclusions.
Our results revealed the potential relationships between gut microbiota and GO-related traits in the combination of microbial effects.
This study may provide a new insight into the interaction between the intestinal microbiota and TRAb-associated immune responses in GO patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Ting-Ting& Hua, Lin& Wang, Hua& Xin, Zhong. 2019. The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Ting-Ting…[et al.]. The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1165137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Ting-Ting& Hua, Lin& Wang, Hua& Xin, Zhong. The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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