The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy
Joint Authors
Hua, Lin
Xin, Zhong
Shi, Ting-Ting
Wang, Hua
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background and Objective.
A previous study reported alterations in the intestinal microbiota in patients with Graves’ orbitopathy (GO).
Thyrotropin receptor autoantibody (TRAb) stimulates orbital and periorbital tissues and plays a pivotal role in the development of GO.
However, the association between gut microbiota and TRAb in GO patients has still remained elusive.
In this study, we explored the relationships between gut microbiota and GO-related traits, in which we applied a metabolic-network-driven analysis to identify GO trait-related modules and extracted significant operational taxonomic units (OTUs).
Methods.
In the present study, we profiled gut microbiota using 16S rRNA gene sequencing in 31 GO patients.
We performed metabolic-network-driven analysis to investigate the association between gut microbiota and GO-related traits (e.g., TRAb, TGAb, and TPOAb) in the combination of microbial effects.
Results.
Applying microbiome network analysis of cooccurrence patterns and analysis of topological properties, we found that s_Prevotella_copri and f_Prevotellaceae showed a significant correlation with TRAb.
In particular, we applied the latent class model to explore the association between gut microbiota and GO-related traits in the combination of microbial effects.
It was revealed that the subjects involved in the latent class model with the higher abundance of s_Prevotella_copri and g_Bacteroides had a higher TRAb level.
Conclusions.
Our results revealed the potential relationships between gut microbiota and GO-related traits in the combination of microbial effects.
This study may provide a new insight into the interaction between the intestinal microbiota and TRAb-associated immune responses in GO patients.
American Psychological Association (APA)
Shi, Ting-Ting& Hua, Lin& Wang, Hua& Xin, Zhong. 2019. The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165137
Modern Language Association (MLA)
Shi, Ting-Ting…[et al.]. The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1165137
American Medical Association (AMA)
Shi, Ting-Ting& Hua, Lin& Wang, Hua& Xin, Zhong. The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165137