Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer
المؤلفون المشاركون
Arsenijevic, Nebojsa
Gajovic, Nevena
Jovanovic, Ivan
Pavlovic, Mladen
Jurisevic, Milena
Mitrovic, Slobodanka
Radosavljevic, Gordana
Pantic, Jelena
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers.
The aim of the study was to determine the expression of IL-32, proinflammatory and angiogenic mediators, in patients with diffuse and intestinal gastric cancer and the relationship with clinicopathological aspects.
Material and Methods.
The tissue samples of diffuse and intestinal types of tumor of 70 patients with gastric cancer were analyzed.
Expression of IL-32, VEGF, IL-17, and CD31 was measured by immunohistochemistry.
Results.
IL-32 expression was significantly lower in tissue samples from patients with diffuse type of gastric cancer that is also a severe and more progressive form (TNM stages III and IV, poor histological differentiation, and higher nuclear grade III).
Expression of IL-17 was also decreased in patients with diffuse type of gastric cancer.
Microvascular density was diminished in diffuse type of gastric cancer.
Conclusions.
Downregulated expression of IL-32 in tumor tissue of patients with diffuse type of gastric cancer may implicate on its role in limiting ongoing proinflammatory and proangiogenic processes.
This emphasizes on unrecognized role of IL-32 in biology of diffuse type of gastric cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pavlovic, Mladen& Gajovic, Nevena& Jurisevic, Milena& Mitrovic, Slobodanka& Radosavljevic, Gordana& Pantic, Jelena…[et al.]. 2018. Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165331
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pavlovic, Mladen…[et al.]. Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1165331
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pavlovic, Mladen& Gajovic, Nevena& Jurisevic, Milena& Mitrovic, Slobodanka& Radosavljevic, Gordana& Pantic, Jelena…[et al.]. Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165331
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165331
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر