Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer
Joint Authors
Arsenijevic, Nebojsa
Gajovic, Nevena
Jovanovic, Ivan
Pavlovic, Mladen
Jurisevic, Milena
Mitrovic, Slobodanka
Radosavljevic, Gordana
Pantic, Jelena
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers.
The aim of the study was to determine the expression of IL-32, proinflammatory and angiogenic mediators, in patients with diffuse and intestinal gastric cancer and the relationship with clinicopathological aspects.
Material and Methods.
The tissue samples of diffuse and intestinal types of tumor of 70 patients with gastric cancer were analyzed.
Expression of IL-32, VEGF, IL-17, and CD31 was measured by immunohistochemistry.
Results.
IL-32 expression was significantly lower in tissue samples from patients with diffuse type of gastric cancer that is also a severe and more progressive form (TNM stages III and IV, poor histological differentiation, and higher nuclear grade III).
Expression of IL-17 was also decreased in patients with diffuse type of gastric cancer.
Microvascular density was diminished in diffuse type of gastric cancer.
Conclusions.
Downregulated expression of IL-32 in tumor tissue of patients with diffuse type of gastric cancer may implicate on its role in limiting ongoing proinflammatory and proangiogenic processes.
This emphasizes on unrecognized role of IL-32 in biology of diffuse type of gastric cancer.
American Psychological Association (APA)
Pavlovic, Mladen& Gajovic, Nevena& Jurisevic, Milena& Mitrovic, Slobodanka& Radosavljevic, Gordana& Pantic, Jelena…[et al.]. 2018. Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165331
Modern Language Association (MLA)
Pavlovic, Mladen…[et al.]. Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1165331
American Medical Association (AMA)
Pavlovic, Mladen& Gajovic, Nevena& Jurisevic, Milena& Mitrovic, Slobodanka& Radosavljevic, Gordana& Pantic, Jelena…[et al.]. Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165331