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Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease
المؤلفون المشاركون
Elsaadany, Basma Abdelaleem
Ahmed, Eman Magdy
Aghbary, Sana Maher Hasan
المصدر
International Journal of Dentistry
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention.
Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatments is supported by strong clinical evidence.
Objective.
This systematic review aims to determine the clinical efficacy and safety of topical corticosteroids for the management of the mucosal alterations of oral cGVHD.
Data Sources.
Electronic search of different databases was conducted: PubMed, Cochrane library, Grey literature, WHO, and clinical trials.gov for clinical trial registration as well as hand search in the references of relevant articles up to November 2016.
Data Extraction.
Extracted pieces of information were intervention, population, sample sizes, and outcomes.
Data Synthesis.
Six studies were included: 2 randomized clinical trials (RCTs), 3 cohort studies, and 1 pre-post clinical trial.
Results.
There is a limited evidence concerning clinical efficacy of topical corticosteroids.
Clobetasol, dexamethasone, and budesonide were the topical corticosteroid of choice.
The highest level of evidence score was given to clobetasol followed by budesonide with a lower evidence level.
Conclusion.
All three topical corticosteroid preparations are effective for management of oral chronic GVHD with minimal easily avoided side effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elsaadany, Basma Abdelaleem& Ahmed, Eman Magdy& Aghbary, Sana Maher Hasan. 2017. Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease. International Journal of Dentistry،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1165481
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elsaadany, Basma Abdelaleem…[et al.]. Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease. International Journal of Dentistry No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1165481
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elsaadany, Basma Abdelaleem& Ahmed, Eman Magdy& Aghbary, Sana Maher Hasan. Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease. International Journal of Dentistry. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1165481
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165481
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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