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Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease
Joint Authors
Elsaadany, Basma Abdelaleem
Ahmed, Eman Magdy
Aghbary, Sana Maher Hasan
Source
International Journal of Dentistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention.
Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatments is supported by strong clinical evidence.
Objective.
This systematic review aims to determine the clinical efficacy and safety of topical corticosteroids for the management of the mucosal alterations of oral cGVHD.
Data Sources.
Electronic search of different databases was conducted: PubMed, Cochrane library, Grey literature, WHO, and clinical trials.gov for clinical trial registration as well as hand search in the references of relevant articles up to November 2016.
Data Extraction.
Extracted pieces of information were intervention, population, sample sizes, and outcomes.
Data Synthesis.
Six studies were included: 2 randomized clinical trials (RCTs), 3 cohort studies, and 1 pre-post clinical trial.
Results.
There is a limited evidence concerning clinical efficacy of topical corticosteroids.
Clobetasol, dexamethasone, and budesonide were the topical corticosteroid of choice.
The highest level of evidence score was given to clobetasol followed by budesonide with a lower evidence level.
Conclusion.
All three topical corticosteroid preparations are effective for management of oral chronic GVHD with minimal easily avoided side effects.
American Psychological Association (APA)
Elsaadany, Basma Abdelaleem& Ahmed, Eman Magdy& Aghbary, Sana Maher Hasan. 2017. Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease. International Journal of Dentistry،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1165481
Modern Language Association (MLA)
Elsaadany, Basma Abdelaleem…[et al.]. Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease. International Journal of Dentistry No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1165481
American Medical Association (AMA)
Elsaadany, Basma Abdelaleem& Ahmed, Eman Magdy& Aghbary, Sana Maher Hasan. Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease. International Journal of Dentistry. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1165481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165481