Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches
المؤلفون المشاركون
Parente, Paola
Covelli, Claudia
Remo, Andrea
Latiano, Tiziana Pia
Graziano, Paolo
Maiello, Evaristo
Olivieri, Nunzio
Giordano, Guido
Pancione, Massimo
Parcesepe, Pietro
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-18
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Pancreatic ductal adenocarcinoma is a lethal disease for which radical surgery and chemotherapy represent the only curative options for a small proportion of patients.
Recently, FOLFIRINOX and nab-paclitaxel plus gemcitabine have improved the survival of metastatic patients but prognosis remains poor.
A pancreatic tumor microenvironment is a dynamic milieu of cellular and acellular elements, and it represents one of the major limitations to chemotherapy efficacy.
The continued crosstalk between cancer cells and the surrounding microenvironment causes immunosuppression within pancreatic immune infiltrate increasing tumor aggressiveness.
Several potential targets have been identified among tumor microenvironment components, and different therapeutic approaches are under investigation.
In this article, we provide a qualitative literature review about the crosstalk between the tumor microenvironment components and immune system in pancreatic cancer.
Finally, we discuss potential therapeutic strategies targeting the tumor microenvironment and we show the ongoing trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Parente, Paola& Parcesepe, Pietro& Covelli, Claudia& Olivieri, Nunzio& Remo, Andrea& Pancione, Massimo…[et al.]. 2018. Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1165554
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Parente, Paola…[et al.]. Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches. Gastroenterology Research and Practice No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1165554
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Parente, Paola& Parcesepe, Pietro& Covelli, Claudia& Olivieri, Nunzio& Remo, Andrea& Pancione, Massimo…[et al.]. Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1165554
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165554
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر