Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches
Joint Authors
Parente, Paola
Covelli, Claudia
Remo, Andrea
Latiano, Tiziana Pia
Graziano, Paolo
Maiello, Evaristo
Olivieri, Nunzio
Giordano, Guido
Pancione, Massimo
Parcesepe, Pietro
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Pancreatic ductal adenocarcinoma is a lethal disease for which radical surgery and chemotherapy represent the only curative options for a small proportion of patients.
Recently, FOLFIRINOX and nab-paclitaxel plus gemcitabine have improved the survival of metastatic patients but prognosis remains poor.
A pancreatic tumor microenvironment is a dynamic milieu of cellular and acellular elements, and it represents one of the major limitations to chemotherapy efficacy.
The continued crosstalk between cancer cells and the surrounding microenvironment causes immunosuppression within pancreatic immune infiltrate increasing tumor aggressiveness.
Several potential targets have been identified among tumor microenvironment components, and different therapeutic approaches are under investigation.
In this article, we provide a qualitative literature review about the crosstalk between the tumor microenvironment components and immune system in pancreatic cancer.
Finally, we discuss potential therapeutic strategies targeting the tumor microenvironment and we show the ongoing trials.
American Psychological Association (APA)
Parente, Paola& Parcesepe, Pietro& Covelli, Claudia& Olivieri, Nunzio& Remo, Andrea& Pancione, Massimo…[et al.]. 2018. Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1165554
Modern Language Association (MLA)
Parente, Paola…[et al.]. Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches. Gastroenterology Research and Practice No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1165554
American Medical Association (AMA)
Parente, Paola& Parcesepe, Pietro& Covelli, Claudia& Olivieri, Nunzio& Remo, Andrea& Pancione, Massimo…[et al.]. Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1165554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165554