Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs
المؤلفون المشاركون
Shang, Peng
Li, Wenting
Liu, Gang
Zhang, Jian
Li, Mengrou
Wu, Lvcao
Wang, Kejun
Chamba, Yangzom
المصدر
International Journal of Genomics
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Tibetan pigs from the Tibetan Plateau are characterized with a significant phenotypic difference relative to lowland pigs.
In this study, a significant difference of the fatness and fatty acid composition traits was observed between the Tibetan and Yorkshire pigs.
To uncover the involved mechanism, the expression profile of long noncoding RNAs (lncRNAs) and genes was compared between them.
After serial filtered steps, 1,964 lncRNAs were obtained through our computational pipeline.
In total, 63 and 715 lncRNAs and genes were identified to be differentially expressed.
Evidence from cis- and trans-targeting analysis of lncRNAs demonstrated that some lncRNAs, such as MSTRG.14097 and MSTRG.8034, played important roles in the fatness and fatty acid composition traits.
Bioinformatics analysis revealed that many candidate genes were responsible for the two traits.
Of these, FASN, ACACA, SCD, ME3, PDHB, ACSS1, ACSS2, and ACLY were identified, which functioned in regulating the level of hexadecanoic acid, hexadecenoic acid, octadecenoic acid, and monounsaturated fatty acid.
And LPGAT1, PDK4, ACAA1, and ADIPOQ were associated with the content of stearic acid, octadecadienoic acid, and polyunsaturated fatty acid.
Candidate genes, which were responsible for fatness trait, consisted of FGF2, PLAG1, ADIPOQ, IRX3, MIF, IL-34, ADAM8, HMOX1, Vav1, and TLR8.
In addition, association analysis also revealed that 34 and 57 genes significantly correlated to the fatness and fatty acid composition trait, respectively.
Working out the mechanism caused by these lncRNAs and candidate genes is proven to be complicated but is invaluable to our understanding of fatness and fatty acid composition traits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shang, Peng& Li, Wenting& Liu, Gang& Zhang, Jian& Li, Mengrou& Wu, Lvcao…[et al.]. 2019. Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs. International Journal of Genomics،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165640
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shang, Peng…[et al.]. Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs. International Journal of Genomics No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1165640
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shang, Peng& Li, Wenting& Liu, Gang& Zhang, Jian& Li, Mengrou& Wu, Lvcao…[et al.]. Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs. International Journal of Genomics. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165640
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165640
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر