Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs
Joint Authors
Shang, Peng
Li, Wenting
Liu, Gang
Zhang, Jian
Li, Mengrou
Wu, Lvcao
Wang, Kejun
Chamba, Yangzom
Source
International Journal of Genomics
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Tibetan pigs from the Tibetan Plateau are characterized with a significant phenotypic difference relative to lowland pigs.
In this study, a significant difference of the fatness and fatty acid composition traits was observed between the Tibetan and Yorkshire pigs.
To uncover the involved mechanism, the expression profile of long noncoding RNAs (lncRNAs) and genes was compared between them.
After serial filtered steps, 1,964 lncRNAs were obtained through our computational pipeline.
In total, 63 and 715 lncRNAs and genes were identified to be differentially expressed.
Evidence from cis- and trans-targeting analysis of lncRNAs demonstrated that some lncRNAs, such as MSTRG.14097 and MSTRG.8034, played important roles in the fatness and fatty acid composition traits.
Bioinformatics analysis revealed that many candidate genes were responsible for the two traits.
Of these, FASN, ACACA, SCD, ME3, PDHB, ACSS1, ACSS2, and ACLY were identified, which functioned in regulating the level of hexadecanoic acid, hexadecenoic acid, octadecenoic acid, and monounsaturated fatty acid.
And LPGAT1, PDK4, ACAA1, and ADIPOQ were associated with the content of stearic acid, octadecadienoic acid, and polyunsaturated fatty acid.
Candidate genes, which were responsible for fatness trait, consisted of FGF2, PLAG1, ADIPOQ, IRX3, MIF, IL-34, ADAM8, HMOX1, Vav1, and TLR8.
In addition, association analysis also revealed that 34 and 57 genes significantly correlated to the fatness and fatty acid composition trait, respectively.
Working out the mechanism caused by these lncRNAs and candidate genes is proven to be complicated but is invaluable to our understanding of fatness and fatty acid composition traits.
American Psychological Association (APA)
Shang, Peng& Li, Wenting& Liu, Gang& Zhang, Jian& Li, Mengrou& Wu, Lvcao…[et al.]. 2019. Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs. International Journal of Genomics،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165640
Modern Language Association (MLA)
Shang, Peng…[et al.]. Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs. International Journal of Genomics No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1165640
American Medical Association (AMA)
Shang, Peng& Li, Wenting& Liu, Gang& Zhang, Jian& Li, Mengrou& Wu, Lvcao…[et al.]. Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs. International Journal of Genomics. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165640