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Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis
المؤلفون المشاركون
Wang, Jing
Li, Da
Xing, Hai-Bo
Hu, Hong
Huang, Chang-Xin
Wang, Yanling
Tong, Mengting
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
CA 19-9 and carcinoembryonic antigen (CEA) are widely used for the diagnosis of pancreatic cancer.
The purpose of the present study was to compare the diagnostic value of CA 19-9 with CEA for pancreatic cancer.
Methods.
The studies were obtained from electronic searches conducted in PubMed, Embase, and Cochrane Library databases until December 2017.
The keywords included diagnosis of pancreatic cancer, CA 19-9, and CEA.
The ratio of sensitivity, the specificity, the diagnostic odds ratio (DOR), and the summary of the receiver operating characteristic (SROC) with regard to CA 19-9 and CEA were measured using the random effects model.
The current study included 13 studies that comprised 4,537 participants and 1,277 patients with pancreatic cancer.
Results.
The levels of CA 19-9 for use for the detection of pancreatic cancer were associated with higher sensitivity (ratio of sensitivity: 1.54; 1.31–1.81; P<0.001), DOR (DOR: 3.50; 95% CI: 2.24–5.45; P<0.001), and AUC (ratio of AUC: 1.24; 95% CI: 1.15–1.33; P<0.001) compared with the variable CEA, while no significant difference between CA 19-9 and CEA was noted with regard to specificity (ratio of specificity: 0.97; 95% CI: 0.89–1.06; P=0.517).
The findings of the subgroup analyses suggested that different cutoff values of CA 19-9 and CEA might affect the diagnostic value.
Conclusions.
The findings of the present study indicated that CA 19-9 levels were associated with higher sensitivity, DOR, and AUC compared with the corresponding levels of CEA with regard to the diagnosis of pancreatic cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xing, Hai-Bo& Wang, Jing& Wang, Yanling& Tong, Mengting& Hu, Hong& Huang, Chang-Xin…[et al.]. 2018. Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165754
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xing, Hai-Bo…[et al.]. Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1165754
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xing, Hai-Bo& Wang, Jing& Wang, Yanling& Tong, Mengting& Hu, Hong& Huang, Chang-Xin…[et al.]. Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165754
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165754
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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