Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis
Joint Authors
Wang, Jing
Li, Da
Xing, Hai-Bo
Hu, Hong
Huang, Chang-Xin
Wang, Yanling
Tong, Mengting
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
CA 19-9 and carcinoembryonic antigen (CEA) are widely used for the diagnosis of pancreatic cancer.
The purpose of the present study was to compare the diagnostic value of CA 19-9 with CEA for pancreatic cancer.
Methods.
The studies were obtained from electronic searches conducted in PubMed, Embase, and Cochrane Library databases until December 2017.
The keywords included diagnosis of pancreatic cancer, CA 19-9, and CEA.
The ratio of sensitivity, the specificity, the diagnostic odds ratio (DOR), and the summary of the receiver operating characteristic (SROC) with regard to CA 19-9 and CEA were measured using the random effects model.
The current study included 13 studies that comprised 4,537 participants and 1,277 patients with pancreatic cancer.
Results.
The levels of CA 19-9 for use for the detection of pancreatic cancer were associated with higher sensitivity (ratio of sensitivity: 1.54; 1.31–1.81; P<0.001), DOR (DOR: 3.50; 95% CI: 2.24–5.45; P<0.001), and AUC (ratio of AUC: 1.24; 95% CI: 1.15–1.33; P<0.001) compared with the variable CEA, while no significant difference between CA 19-9 and CEA was noted with regard to specificity (ratio of specificity: 0.97; 95% CI: 0.89–1.06; P=0.517).
The findings of the subgroup analyses suggested that different cutoff values of CA 19-9 and CEA might affect the diagnostic value.
Conclusions.
The findings of the present study indicated that CA 19-9 levels were associated with higher sensitivity, DOR, and AUC compared with the corresponding levels of CEA with regard to the diagnosis of pancreatic cancer.
American Psychological Association (APA)
Xing, Hai-Bo& Wang, Jing& Wang, Yanling& Tong, Mengting& Hu, Hong& Huang, Chang-Xin…[et al.]. 2018. Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165754
Modern Language Association (MLA)
Xing, Hai-Bo…[et al.]. Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1165754
American Medical Association (AMA)
Xing, Hai-Bo& Wang, Jing& Wang, Yanling& Tong, Mengting& Hu, Hong& Huang, Chang-Xin…[et al.]. Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165754