![](/images/graphics-bg.png)
Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries
المؤلفون المشاركون
Reis, Steven E.
Cooper, Margaret E.
Shaffer, John R.
Feingold, Eleanor
Levy, Steven M.
Lewis, D. D.
Vanyukov, M. M.
Maher, B. S.
Slayton, R. L.
Willing, M. C.
Weyant, R. J.
McNeil, Daniel W.
Marazita, Mary L.
Vieira, Alexandre Rezende
Crout, Richard
المصدر
International Journal of Dentistry
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Matrix metalloproteinases (MMPs), which degrade extracellular proteins as part of a variety of physiological processes, and their inhibitors have been implicated in the dental caries process.
Here we investigated 28 genetic variants spanning the MMP10, MMP14, and MMP16 genes to detect association with dental caries experience in 13 age- and race-stratified (n=3,587) samples from 6 parent studies.
Analyses were performed separately for each sample, and results were combined across samples by meta-analysis.
Two SNPs (rs2046315 and rs10429371) upstream of MMP16 were significantly associated with caries in an individual sample of white adults and via meta-analysis across 8 adult samples after gene-wise adjustment for multiple comparisons.
Noteworthy is SNP rs2046315 (p=8.14×10-8) association with caries in white adults.
This SNP was originally nominated in a genome-wide-association study (GWAS) of dental caries in a sample of white adults and yielded associations in a subsequent GWAS of surface level caries in white adults as well.
Therefore, in our study, we were able to recapture the association between rs2046315 and dental caries in white adults.
Although we did not strengthen evidence that MMPs 10, 14, and 16 influence caries risk, MMP16 is still a likely candidate gene to pursue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lewis, D. D.& Shaffer, John R.& Feingold, Eleanor& Cooper, Margaret E.& Vanyukov, M. M.& Maher, B. S.…[et al.]. 2017. Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries. International Journal of Dentistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1165761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lewis, D. D.…[et al.]. Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries. International Journal of Dentistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1165761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lewis, D. D.& Shaffer, John R.& Feingold, Eleanor& Cooper, Margaret E.& Vanyukov, M. M.& Maher, B. S.…[et al.]. Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries. International Journal of Dentistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1165761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)