Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries
Joint Authors
Reis, Steven E.
Cooper, Margaret E.
Shaffer, John R.
Feingold, Eleanor
Levy, Steven M.
Lewis, D. D.
Vanyukov, M. M.
Maher, B. S.
Slayton, R. L.
Willing, M. C.
Weyant, R. J.
McNeil, Daniel W.
Marazita, Mary L.
Vieira, Alexandre Rezende
Crout, Richard
Source
International Journal of Dentistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Matrix metalloproteinases (MMPs), which degrade extracellular proteins as part of a variety of physiological processes, and their inhibitors have been implicated in the dental caries process.
Here we investigated 28 genetic variants spanning the MMP10, MMP14, and MMP16 genes to detect association with dental caries experience in 13 age- and race-stratified (n=3,587) samples from 6 parent studies.
Analyses were performed separately for each sample, and results were combined across samples by meta-analysis.
Two SNPs (rs2046315 and rs10429371) upstream of MMP16 were significantly associated with caries in an individual sample of white adults and via meta-analysis across 8 adult samples after gene-wise adjustment for multiple comparisons.
Noteworthy is SNP rs2046315 (p=8.14×10-8) association with caries in white adults.
This SNP was originally nominated in a genome-wide-association study (GWAS) of dental caries in a sample of white adults and yielded associations in a subsequent GWAS of surface level caries in white adults as well.
Therefore, in our study, we were able to recapture the association between rs2046315 and dental caries in white adults.
Although we did not strengthen evidence that MMPs 10, 14, and 16 influence caries risk, MMP16 is still a likely candidate gene to pursue.
American Psychological Association (APA)
Lewis, D. D.& Shaffer, John R.& Feingold, Eleanor& Cooper, Margaret E.& Vanyukov, M. M.& Maher, B. S.…[et al.]. 2017. Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries. International Journal of Dentistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1165761
Modern Language Association (MLA)
Lewis, D. D.…[et al.]. Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries. International Journal of Dentistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1165761
American Medical Association (AMA)
Lewis, D. D.& Shaffer, John R.& Feingold, Eleanor& Cooper, Margaret E.& Vanyukov, M. M.& Maher, B. S.…[et al.]. Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries. International Journal of Dentistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1165761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165761