Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma
المؤلفون المشاركون
Shelat, Vishalkumar Girishchandra
Ye, MaDong
Kabir, T.
Mohd Noor, N. A.
Woon, W.
Junnarkar, S. P.
المصدر
International Journal of Hepatology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
In recent years, inflammation-based scoring systems have been reported to predict survival in Hepatocellular Carcinoma (HCC).
The aim of our study was to validate combined preoperative Neutrophil-to-Lymphocyte ratio (NLR)-Platelet-to-Lymphocyte ratio (PLR) in predicting overall survival (OS) and recurrence free survival (RFS) in patients who underwent curative resection for HCC.
Methods.
We conducted a retrospective study of HCC patients underwent liver resection with curative intent from January 2010 to December 2013.
Receiver-operating characteristic (ROC) curve analysis was used to determine the optimal cut-off values for NLR and PLR.
Patients with both NLR and PLR elevated were allocated a score of 2; patients showing one or neither of these indices elevated were accorded a score of 1 or 0, respectively.
Results.
132 patients with a median age of 66 years (range 18-87) underwent curative resection for HCC.
Overall morbidity was 30.3%, 30-day mortality was 2.3%, and 90-day mortality was 6.8%.
At a median follow-up of 24 months (range 1-88), 25% patients died, and 40.9% had recurrence.
On multivariate analysis, elevated preoperative NLR-PLR was predictive of both OS (HR 2.496; CI 1.156-5.389; p=0.020) and RFS (HR 1.917; CI 1.161-3.166; p=0.011).
The 5-year OS was 76% for NLR-PLR=0 group, 21.7% for the NLR-PLR=1 group, and 61.1% for the NLR-PLR=2 group, respectively.
The 5-year RFS was 39.3% for the NLR-PLR=0 group, 18.4% for the NLR-PLR=1 group, and 21.1% for the NLR-PLR=2 group, respectively.
Conclusion.
The preoperative NLR-PLR is predictive of both OS and RFS in patients with HCC undergoing curative liver resection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kabir, T.& Ye, MaDong& Mohd Noor, N. A.& Woon, W.& Junnarkar, S. P.& Shelat, Vishalkumar Girishchandra. 2019. Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma. International Journal of Hepatology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165931
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kabir, T.…[et al.]. Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma. International Journal of Hepatology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1165931
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kabir, T.& Ye, MaDong& Mohd Noor, N. A.& Woon, W.& Junnarkar, S. P.& Shelat, Vishalkumar Girishchandra. Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma. International Journal of Hepatology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165931
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165931
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر