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Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma
Joint Authors
Shelat, Vishalkumar Girishchandra
Ye, MaDong
Kabir, T.
Mohd Noor, N. A.
Woon, W.
Junnarkar, S. P.
Source
International Journal of Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
In recent years, inflammation-based scoring systems have been reported to predict survival in Hepatocellular Carcinoma (HCC).
The aim of our study was to validate combined preoperative Neutrophil-to-Lymphocyte ratio (NLR)-Platelet-to-Lymphocyte ratio (PLR) in predicting overall survival (OS) and recurrence free survival (RFS) in patients who underwent curative resection for HCC.
Methods.
We conducted a retrospective study of HCC patients underwent liver resection with curative intent from January 2010 to December 2013.
Receiver-operating characteristic (ROC) curve analysis was used to determine the optimal cut-off values for NLR and PLR.
Patients with both NLR and PLR elevated were allocated a score of 2; patients showing one or neither of these indices elevated were accorded a score of 1 or 0, respectively.
Results.
132 patients with a median age of 66 years (range 18-87) underwent curative resection for HCC.
Overall morbidity was 30.3%, 30-day mortality was 2.3%, and 90-day mortality was 6.8%.
At a median follow-up of 24 months (range 1-88), 25% patients died, and 40.9% had recurrence.
On multivariate analysis, elevated preoperative NLR-PLR was predictive of both OS (HR 2.496; CI 1.156-5.389; p=0.020) and RFS (HR 1.917; CI 1.161-3.166; p=0.011).
The 5-year OS was 76% for NLR-PLR=0 group, 21.7% for the NLR-PLR=1 group, and 61.1% for the NLR-PLR=2 group, respectively.
The 5-year RFS was 39.3% for the NLR-PLR=0 group, 18.4% for the NLR-PLR=1 group, and 21.1% for the NLR-PLR=2 group, respectively.
Conclusion.
The preoperative NLR-PLR is predictive of both OS and RFS in patients with HCC undergoing curative liver resection.
American Psychological Association (APA)
Kabir, T.& Ye, MaDong& Mohd Noor, N. A.& Woon, W.& Junnarkar, S. P.& Shelat, Vishalkumar Girishchandra. 2019. Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma. International Journal of Hepatology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165931
Modern Language Association (MLA)
Kabir, T.…[et al.]. Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma. International Journal of Hepatology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1165931
American Medical Association (AMA)
Kabir, T.& Ye, MaDong& Mohd Noor, N. A.& Woon, W.& Junnarkar, S. P.& Shelat, Vishalkumar Girishchandra. Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma. International Journal of Hepatology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165931