Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites

المؤلفون المشاركون

Prabhu, Mukhyaprana
Gangula, Rahul Sai
Stanley, Weena

المصدر

International Journal of Hepatology

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-06-02

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Context.

Ability of SAAG to differentiate malignant ascites from other aetiologies like tubercular peritonitis is a major problem.

Alternate screening test is needed for differentiating ascites due to malignancy from those due to tubercular peritonitis.

Aims.

To study the diagnostic utility of serum ascites lipid gradients and serum ascites protein gradients in pathophysiological differentiation of ascites.

Settings and Design.

The present study is a prospective, descriptive, hospital-based, cross-sectional study.

Methods and Material.

The study was conducted on patients with ascites who were admitted to General Medicine Department, Kasturba Hospital, Manipal.

The study included 60 patients with ascites of different etiologies (liver cirrhosis, tubercular peritonitis, and malignant ascites).

All of them had undergone clinical, laboratory, and imaging investigations and were treated as per standard of care.

All patients underwent abdominal paracentesis, and fluid samples were sent for analysis.

Statistical Analysis Used.

ANOVA, Kruskal-Wallis H test, and ROC curve analysis.

Results.

Among the gradients, only SAPG and SAAG had over all statistical significance (<0.005) among the groups, but no significance between malignancy and tubercular peritonitis had been observed.

Similarly all the ascitic fluid parameters measured had an overall statistical significance (<0.005), but there was no significant difference observed between malignancy and tubercular peritonitis groups.

However, ascitic fluid and serum HDL cholesterol had a statistical significance (<0.05) between malignancy and tubercular peritonitis.

Conclusions.

With a cut-off value of 4, SAPG is one of best screening tests in differentiation of cirrhotic with noncirrhotic ascites when compared with SAAG, whereas it is a poor parameter with high sensitivity and very low specificity in differentiation of malignant with nonmalignant ascites.

Also the present study reveals HDL cholesterol levels in ascitic fluid to be a valuable marker with higher sensitivity and specificity in differentiation of malignancy and tuberculosis peritonitis (i.e., differentiation of low SAAG ascites).

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Prabhu, Mukhyaprana& Gangula, Rahul Sai& Stanley, Weena. 2019. Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites. International Journal of Hepatology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1165936

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Prabhu, Mukhyaprana…[et al.]. Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites. International Journal of Hepatology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1165936

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Prabhu, Mukhyaprana& Gangula, Rahul Sai& Stanley, Weena. Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites. International Journal of Hepatology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1165936

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1165936