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Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites
Joint Authors
Prabhu, Mukhyaprana
Gangula, Rahul Sai
Stanley, Weena
Source
International Journal of Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Context.
Ability of SAAG to differentiate malignant ascites from other aetiologies like tubercular peritonitis is a major problem.
Alternate screening test is needed for differentiating ascites due to malignancy from those due to tubercular peritonitis.
Aims.
To study the diagnostic utility of serum ascites lipid gradients and serum ascites protein gradients in pathophysiological differentiation of ascites.
Settings and Design.
The present study is a prospective, descriptive, hospital-based, cross-sectional study.
Methods and Material.
The study was conducted on patients with ascites who were admitted to General Medicine Department, Kasturba Hospital, Manipal.
The study included 60 patients with ascites of different etiologies (liver cirrhosis, tubercular peritonitis, and malignant ascites).
All of them had undergone clinical, laboratory, and imaging investigations and were treated as per standard of care.
All patients underwent abdominal paracentesis, and fluid samples were sent for analysis.
Statistical Analysis Used.
ANOVA, Kruskal-Wallis H test, and ROC curve analysis.
Results.
Among the gradients, only SAPG and SAAG had over all statistical significance (<0.005) among the groups, but no significance between malignancy and tubercular peritonitis had been observed.
Similarly all the ascitic fluid parameters measured had an overall statistical significance (<0.005), but there was no significant difference observed between malignancy and tubercular peritonitis groups.
However, ascitic fluid and serum HDL cholesterol had a statistical significance (<0.05) between malignancy and tubercular peritonitis.
Conclusions.
With a cut-off value of 4, SAPG is one of best screening tests in differentiation of cirrhotic with noncirrhotic ascites when compared with SAAG, whereas it is a poor parameter with high sensitivity and very low specificity in differentiation of malignant with nonmalignant ascites.
Also the present study reveals HDL cholesterol levels in ascitic fluid to be a valuable marker with higher sensitivity and specificity in differentiation of malignancy and tuberculosis peritonitis (i.e., differentiation of low SAAG ascites).
American Psychological Association (APA)
Prabhu, Mukhyaprana& Gangula, Rahul Sai& Stanley, Weena. 2019. Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites. International Journal of Hepatology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1165936
Modern Language Association (MLA)
Prabhu, Mukhyaprana…[et al.]. Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites. International Journal of Hepatology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1165936
American Medical Association (AMA)
Prabhu, Mukhyaprana& Gangula, Rahul Sai& Stanley, Weena. Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites. International Journal of Hepatology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1165936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165936