SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity
المؤلفون المشاركون
Karstensen, John G.
Vilmann, Peter
Saftoiu, Adrian
Klausen, Pia
Coskun, Mehmet
Cowland, Jack Bernard
Riis, Lene Buhl
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Small mothers against decapentaplegic (SMAD)4 and SMAD7 are key regulatory components in the immunosuppressive transforming growth factor- (TGF-) β signaling pathway, which is defective in inflammatory bowel disease (IBD).
SMAD4 may play an important role in the pathogenesis of IBD as indicated in experimental models of colitis.
Aims.
To examine the ileal expression levels of SMAD4 and to correlate these with CD disease activity.
Methods.
The material comprised 29 CD patients (13 with active disease, 16 in remission) and 9 asymptomatic patients referred for ileocolonoscopy as part of an adenoma surveillance program serving as controls.
Patients were examined with ileocolonoscopy.
Corresponding ileal biopsies were obtained for histological analysis and assessment of SMAD4 and SMAD7 protein expression by immunohistochemistry (IHC).
Results.
The protein expression of SMAD4 was significantly downregulated in ileal tissue sections from CD patients as compared to healthy controls (p<0.001).
Further, luminal SMAD4 expression was inversely correlated with endoscopic (rs=−0.315; p=0.05) and histopathological activity (rs=−0.40; p=0.013).
Conclusions.
The SMAD4 epithelial protein level was markedly downregulated in CD patients and inversely correlated with disease activity.
This may contribute to defective mucosal TGF-β signaling in active IBD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Klausen, Pia& Karstensen, John G.& Coskun, Mehmet& Saftoiu, Adrian& Vilmann, Peter& Cowland, Jack Bernard…[et al.]. 2018. SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165939
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Klausen, Pia…[et al.]. SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1165939
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Klausen, Pia& Karstensen, John G.& Coskun, Mehmet& Saftoiu, Adrian& Vilmann, Peter& Cowland, Jack Bernard…[et al.]. SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165939
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165939
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر